Synthesis of scyllatoxin-based BH3 domain mimetics with diverse patterns of native disulfide bonds. M. J. K Vince & J. M. Holub. Curr. Protocol., 2022, 2, e256.
PubMed. PDF.
Versatile gold-coupled Te-carbon dots for quantitative monitoring and efficient scavenging of superoxide anions. C. Xu, W. Zhang, R. Wang, S. Tan, J. M. Holub & B. Tang. Anal. Chem., 2021, 93, 9111-9118.
PubMed. PDF.
A novel peptide antagonist of the human growth hormone receptor. R. Basu, K. Nahar, P. Kulkarni, O. Kerekes, M. Sattler, Z. Hall, S. Neggers, J. M. Holub & J. J. Kopchick. J. Biol. Chem., 2021, 296, 100588-100603.
PubMed. PDF.
Novel peptide-based inhibitors of protein kinases. J. M. Holub. In: Next Generation, Kinase Inhibitors, P. Shapiro (ed.). 2020, 169-206. Web. PDF.
Monitoring ligand-mediated helix 12 transitions within the human estrogen receptor alpha using bipartite tetracysteine display. R. Pokhrel, T. Tang & J. M. Holub. Org. Biomol. Chem., 2020,18, 6063-6071. PubMed. PDF.
Synthesis and biological activity of scyllatoxin-based BH3 domain mimetics containing two disulfide linkages. D. Arachchige & J. M. Holub. Protein J.,2018, 37, 428-443. PubMed. PDF.
Inhibiting phosphorylation of tau proteins using peptide-based R1-domain mimetics. N. Alqaeisoom, C. Qian, D. Arachchige, R. A. Colvin & J. M. Holub. Int. J. Pept. Res. Ther.,2018,25, 447-463. Web. PDF.
Intracellular zinc increase affects phosphorylation state and subcellular localization of protein kinase C delta. K. G. Slepchenko, J. M. Holub & Y. V. Li. Cell. Signal.,2018,44, 148-157. PubMed. PDF.
Small scaffolds, big potential: Developing miniature proteins as therapeutic agents. J. M. Holub. Drug Dev. Res.,2017,78, 268-282. PubMed. PDF.
Role of single disulfide linkages in the folding and activity of scyllatoxin-based BH3 domain mimetics. D. Arachchige, M. M. Harris, Z. Coon, J. Carlsen & J. M. Holub. J. Pept. Sci.,2017,23, 367-373. PubMed. PDF.
Targeting anti-apoptotic Bcl2 proteins with scyllatoxin-based BH3 domain mimetics. M. M. Harris, Z. Coon, N. Alqaeisoom, B. Swords & J. M. Holub. Org. Biomol. Chem.,2016,14, 440-446. PubMed. PDF.
Improved assays for determining the cytosolic access of peptides, proteins and their mimetics J. M. Holub, J. R. LaRochelle, J. S. Appelbaum & A. Schepartz. Biochemistry,2013,52, 9036-9046. PubMed. PDF.
Crafting precise multivalent architectures P. M. Levine, T. P. Carberry, J. M. Holub & K. Kirshenbaum. Med. Chem. Commun.,2013,4, 493-509. Web. PDF.
Arginine topology controls escape of minimally cationic proteins form early endosomes to the cytoplasm J. S. Appelbaum, J. R. LaRochelle, B. A. Smith, D. M. Balkin, J. M. Holub & A. Schepartz. Chem. Biol., 2012,7, 819-830. PubMed. PDF.
Modulation of the human estrogen receptor alpha by estradiol-peptidomimetic conjugates J. M. Holub, M. J. Garabedian & K. Kirshenbaum. Mol. Biosys., 2011,7, 337-345. PubMed. PDF.
Lipid-lowering effects of polymers derived from halophenyl pyrroles B. S. Burnham, J. D. Berkowitz, B. McCranor, M. Cooper, K. McCann, K. Pillitteri, J. Hallback, L. Bergh, L. Gofman, M. Melendez, J. M. Holub, K. Morie & C. E. Carraher, Jr. Lett. Drug Des. Discov., 2011, 8, 544-549. Web. PDF.
Tricks with clicks: Modification of peptidomimetic oligomers via copper-catalyzed azide-alkyne [3+2] cycloaddition J. M. Holub & K. Kirshenbaum. Chem. Soc. Rev., 2010,39, 1325-1337. PubMed. PDF.
Peptide cyclization and cyclodimerization by CuI-mediated azide-alkyne cycloaddition. R. Jagasia, J. M. Holub, M. Bollinger, K. Kirshenbaum & M.G. Finn. J. Org. Chem., 2009,74, 2964-2974. PubMed. PDF.
Peptoids on steroids: precise multivalent estradiolpeptidomimetic conjugates generated via azide-alkyne [3+2] cycloaddition reactions. J. M. Holub, M. J. Garabedian & K. Kirshenbaum.QSAR Comb. Sci., 2007,26, 1175-1180. Web. PDF.
Fit to be tied: conformation-directed macrocyclization of peptoid foldamers. J. M. Holub, H. Jang & K. Kirshenbaum. Org. Lett.,2007, 9, 3275-3278. PubMed. PDF.
A conserved RAS/mitogen-activated protein kinase pathway regulates DNA damage-induced cell death postirradiation in Radelegans. J. B. Weidhaas, D. M. Eisenmann, J. M. Holub & S. V. Nallur. . Cancer Res., 2006,66, 10434-10438. PubMed. PDF.
A Caenorhabditis elegans tissue model of radiation-induced reproductive cell death. J. B. Weidhaas, D. M. Eisenmann, J. M. Holub & S. V. Nallur.Proc. Natl. Acad. Sci. USA, 2006,103, 9946-9951. PubMed. PDF.
Clickity-click: highly functionalized peptoid oligomers generated by sequential conjugation reactions on solid phase support J. M. Holub, H. Jang & K. Kirshenbaum. Org. Biomol. Chem., 2006,4, 1497-1502. PubMed. PDF.
Click to fit: versatile polyvalent displays on a peptidomimetic scaffold. H. Jang, A. Farfarman, J. M. Holub & K. Kirshenbaum. Org. Lett., 2005,7, 1951-1954 . PubMed. PDF.
Lipid-lowering effects of ethyl 2-phenacyl-3-aryl-1Hpyrrole-4-carboxylates in rodents. J. M. Holub, K. O’Toole-Colin, A. Getzel, A. Argenti, M. Evans, D. Smith, G. Dalglish, S. Rifat, D. Wilson, B. Taylor, U. Miott, J. Glersaye, S. Lam, B. J. McCranor, J. Berkowitz, R. Miller, L. Lukens, K. Krumpte, J. T. Gupton & B. S. Burnham . Molecules, 2004,9, 134-157. PubMed. PDF.
Synthesis and cytotoxicity of substituted ethyl 2-phenacyl-3-phenylpyrrole-4-carboxylates. M. A. Evans, D. C. Smith, J. M. Holub, A. Argenti, M. Hoff, G. A. Dalglish, D. L. Wilson, B. M. Taylor, J. D. Berkowitz, B. S. Burnham, K. Krumpe, J. T. Gupton, T. C. Scarlett, R. W. Durham, Jr. & I. H. Hall. Arch. Pharm. Pharm. Med. Chem.,2003,336, 181-190. PubMed. PDF.